Biogenic Transporters and Receptors | Brain Metabolism | Pharmacokinetics

A major advantage of PET imaging is that it provides a quantitative measure of ligand uptake. This can be used to calculate and compare the binding potential of different drugs as well as determine the proportion of occupied receptors when a particular dose of a drug is administered.

This data is derived from time-activity curves (TAC) wherein the concentration of radioactivity in different brain regions is plotted across time on a scale that takes into account the weight of the animal, amount of radioactive material administered, etc. This allows for a direct comparison of uptake between animal and session.

The images below show the uptake of C11 labelled Cocaine in two different brain areas across three different Rhesus monkeys (Macaca mulatta).

Directions | Contact Us | ©2006 Yerkes Imaging Center