MRI Publications

Peer-reviewed journal Publications


Wu LM ‡, Jiang L ‡, Sun PZ *, "Investigating the origin of pH-sensitive magnetization transfer ratio asymmetry MRI contrast during the acute stroke – Correction of T1 change reveals the dominant amide proton transfer MRI signal", Magn Reson Med 2020;84:2702–2712. PMID: 32416012 (DOI: 10.1002/mrm.28313)

Joers V, Gunsingh M, Kempf D, Weiss A, Rotterman T, Murray B, Yalcin-Cakmakl G, Voll R, Goodman M, Howell L, Bachevalier J, Green S, Naquib A, Engen P, Keshavarzian A, Barnum C, Nye J, Smith Y, Tansey M. "Microglia, inflammation and gut microbiota responses in a progressive monkey model of Parkinson’s disease: a case series”, Neurobiology of Disease. 2020;144:105027. PMID: 32712266 (DOI: 10.1016/j.nbd.2020.105027)

Maltbie E, Howell L, Sun PZ, Miller R, Gopinath KS *, "Examining fMRI Time-Series Irregularity as a Marker for Local Neural Activity with Pharmacological Manipulations in a Non-human Primate Translational Model," Neurosci Lett 2020 (In Press) PMID: 32315710, PMCID: PMC7266677 (DOI: 10.1016/j.neulet.2020.134984)

Sun PZ *, "Demonstration of pH-specific magnetization transfer and relaxation normalization for pulsed amide proton transfer imaging in an animal model of acute stroke," Magn Reson Med 2020;84(3):1526-1533. PMID: 32080897 (DOI: 10.1002/mrm.28223)

Sun PZ *, "Fast correction of B0 field inhomogeneity for pH-specific magnetization transfer and relaxation normalized amide proton transfer imaging of acute ischemic stroke without Z-spectrum", Magn Reson Med 2020;83(5):1688-97. PMID: 31631414 (DOI: 10.1002/mrm.28040)

Sun PZ *, "Development of intravoxel inhomogeneity correction for chemical exchange saturation transfer (CEST) spectral imaging – A high-resolution field map-based deconvolution algorithm for magnetic field inhomogeneity correction" Magn Reson Med 2020;83:1348-55. PMID: 31628765 (DOI: 10.1002/mrm.28015)

Tan SS, Yang H, Xue S, Qiao J, Salarian M, Hekmatyar K, Meng YG, Mikkavilli R, Pu F, Odubade OY, Harris W, Yushak M, Morales-Tirado V, Mittal P, Sun PZ, Lawson D, Grossniklaus H, Yang JJ *, "Chemokine receptor 4 targeted protein MRI contrast agent for early detection of liver metastases", Science Advances 2020;6(6):eaav7504. PMID: 32083172, PMCID: PMC7007242 (DOI: 10.1126/sciadv.aav7504)

Meng YG, Cheung J, Sun PZ *, "Magnetization-prepared magnetic resonance fingerprinting for relaxation measurement in the presence of semisolid magnetization transfer," Magn Reson Med 2020;84(2):727-737. PMID: 31898839, PMCID: PMC7180097 (DOI: 10.1002/mrm.28159)


Herisson F, Zhou IY, Mawet J, Du S, Barfejani A. Qin T, Sun PZ, Ayata C, Rost N *. Posterior reversible encephalopathy syndrome in stroke-prone spontaneously hypertensive rats on high-salt diet. J Cereb Blood Flow Metab 2019;39:1232-46. PMID: 29350576; PMCID: PMC6668522.

Ji Y, Lu D, Wu LM, Song YQ, Sun PZ *. Preliminary evaluation of accelerated microscopic diffusional kurtosis imaging (µDKI) in a rodent model of epilepsy. Magn Reson Imag 2019;56:90-95. PMID: 30352270; PMCID: PMC6583913.

Ji Y, Paulsen J, Zhou IY, Lu D, Machado P, Qiu BS, Song YQ, Sun PZ *. in vivo microscopic diffusion kurtosis imaging with symmetrized double diffusion encoded EPI. Magn Reson Med 2019;81(1):533-541. PMID: 30260504; PMCID: PMC6258297.

Maltbie EA, Gopinath KS, Howell LL. Effects of ketamine treatment on cocaine-induced reinstatement and disruption of functional connectivity in unanesthetized rhesus monkeys. Psychopharmacology (Berl). 2019;236(7):2105-2118. PMID: 30879118.

Nye J, Dharmadhikari S, Lafata N. Reply to "Peak Skin Dose Estimation in Fluoroscopically Guided Interventions: Is It Necessary?" AJR Am J Roentgenol. 2019 Oct;213(4):W186. PMID: 31536425.
Ball N, Dharmadhikari S, Nye JA. Hallway Conversations in Physics (What Is Peak Skin Dose?). AJR Am J Roentgenol. 2019;212(4):W107-W108. PMID: 30900917.

Wang EF‡, Wu Y‡, Cheung JS, Igarashi T, Wu LM, Zhang XA, Sun PZ *. Refined ischemic tissue demarcation with quantitative tissue pH MRI in an animal model of acute ischemic stroke. Neuroimage 2019;191:610-7. PMID: 30753926; PMCID: PMC6440806.

Zhou IY, Lu DS, Ji Y, Wu LM, Wang EF, Cheung J, Zhang XA, Sun PZ *. Determination of multi-pool contributions to endogenous amide proton transfer effects in global ischemia with high spectral resolution in vivo chemical exchange saturation transfer MRI. Magn Reson Med 2019;81(1):645-652. PMID: 30058148; PMCID: PMC6258351.

Luo J, Turk EA, Gagoski B, Copeland B, Zhou IY, Yang Vanessa, Bibbo C, Robinson JN, Zera C, Barth W, Roberts DJ, Sun PZ *, Grant PE *, "Dynamic Glucose Enhanced MRI of the Human Placenta during Glucose Tolerance Test – A Feasibility Study," Quantitative Imaging in Medicine and Surgery 2019;9(10):1619-27. PMID: 31728306, PMCID: PMC6828580 (DOI: 10.21037/qims.2019.09.16)


Kovacs-Balint Z, Feczko E, Pincus M, Earl E, Miranda-Dominguez O, Howell B, Morin E, Maltbie E, Li L, Steele J, Styner M, Bachevalier J, Fair D, Sanchez M. Early Developmental Trajectories of Functional Connectivity Along the Visual Pathways in Rhesus Monkeys. Cereb Cortex. 2018. PubMed PMID: 30272135.

Li CX, Zhang X. Evaluation of prolonged administration of isoflurane on cerebral blood flow and default mode network in macaque monkeys anesthetized with different maintenance doses. Neurosci Lett. 2018; 662:402-408. PMID: 29055725; PMCID: PMC5722273.

Li CX, Kempf DJ, Tong FC, Yan Y, Xu Z, Connor-Stroud FR, Ford BD, Howell LL, Zhang X. Longitudinal MRI Evaluation of Ischemic Stroke in the Basal Ganglia of a Rhesus Macaque (Macaca mulatta) with Seizures. Comp Med. 2018;68(6):496-502. PMID: 30486918; PMCID: PMC6310199.

Lu DS‡, Jiang YH‡, Ji Y, Zhou IY, Mandeville E, Lo EH, Wang XY, Sun PZ *. Evaluation of graded hemodynamic and metabolic states between diffusion and kurtosis MRI lesions in an animal model of acute ischemic stroke. Am J Roentgenology 2018;22:1-8. PMID: 29470156; NIHMSID 1054518.

Meng Y, Hu X, Zhang X, Bachevalier J. Diffusion tensor imaging reveals microstructural alterations in corpus callosum and associated transcallosal fiber tracts in adult macaques with neonatal hippocampal lesions. Hippocampus. 2018;28:838-845. PMID: 29978933; PMCID: PMC6282702.

Wu Y, Zhou IY, Igarashi T, Longo DL, Aime S, Sun PZ. A generalized ratiometric chemical exchange saturation transfer (CEST) MRI approach for mapping renal pH using iopamidol. Magn Reson Med. 2018 Mar;79(3):1553-1558. PubMed PMID: 28686805; PMCID: PMC5756701.

Wu Y, Zhou IY, Lu DS, Mandeville E, Lo EH, Zheng HR, Sun PZ *, pH-sensitive amide proton transfer effect dominates magnetization transfer asymmetry contrast in acute ischemia — Quantification of multi-pool contribution to in vivo CEST MRI. Magn Reson Med 2018 Mar;79(3):1602-08. PMID: 28733991; PMCID: PMC5775916.

Yin JZ, Sun HZ, Wang ZY, Ni HY, Shen W, Sun PZ *. Diffusion kurtosis imaging of acute infarction: Comparison with routine diffusion and followup MRI. Radio 2018;287(2):651-7. PMID: 29558293; PMCID: PMC5929367.

Zhang X, Yan Y, Tong F, Li CX, Jones B, Wang S, Meng Y, Muly EC, Kempf D, Howell L. Progressive Assessment of Ischemic Injury to White Matter Using Diffusion Tensor Imaging: A Preliminary Study of a Macaque Model of Stroke. Open Neuroimag J. 2018;12:30-41. PMID: 29785226; PMCID: PMC5897992.


Adhikarla V, Zeng F, Votaw JR, Goodman MM, Nye JA. Compartmental modeling of [(11) C]MENET binding to the norepinephrine transporter in the healthy human brain. Nucl Med Biol. 2016;43(5):318-23. PMID: 27150035; PMCID: PMC4860207.

Berro LF, Perez Diaz M, Maltbie E, Howell LL. Effects of the serotonin 2C receptor agonist WAY163909 on the abuse-related effects and mesolimbic dopamine neurochemistry induced by abused stimulants in rhesus monkeys. Psychopharmacology (Berl). 2017;234(17):2607-17. PMID: 28584928; PMCID: PMC5709171.

Dormer JD, Meng Y, Zhang X, Jiang R, Wagner MB, Fei B. Estimating cardiac fiber orientations in pig hearts using registered ultrasound and MR image volumes. Proc SPIE Int Soc Opt Eng. 2017;10139. pii: 101391G. PMID: 30220771; PMCID: PMC6138465.

Heuer E, Jacobs J, Du R, Wang S, Keifer OP, Cintron AF, Dooyema J, Meng Y, Zhang X, Walker LC. Amyloid-Related Imaging Abnormalities in an Aged Squirrel Monkey with Cerebral Amyloid Angiopathy. J Alzheimers Dis. 2017;57:519-530. PMID: 28269776; PMCID: PMC5624788.

Li CX, Zhang X. Effects of Long-Duration Administration of 1% Isoflurane on Resting Cerebral Blood Flow and Default Mode Network in Macaque Monkeys. Brain Connect. 2017;7(2):98-105. PMID: 28030956; PMCID: PMC5359674.

Li CX, Zhang X. Whole body MRI of the non-human primate using a clinical 3T scanner: initial experiences. Quant Imaging Med Surg. 2017;7(2):267-275. PMID: 28516052; PMCID: PMC5418147.

Lipowska M, Jarkas N, Voll RJ, Nye JA, Klenc J, Goodman MM, Taylor AT. Re(CO)(3)([(18)F]FEDA), a novel (18)F PET renal tracer: Radiosynthesis and preclinical evaluation. Nucl Med Biol. 2018;58:42-50. PMID: 29367095; PMCID: PMC5817033.

Maltbie EA, Kaundinya GS, Howell LL. Ketamine and pharmacological imaging: use of functional magnetic resonance imaging to evaluate mechanisms of action. Behav Pharmacol. 2017;28(8):610-22. PMID: 29049083; PMCID: PMC5687297.

Meng Y, Jiang J, Bachevalier J, Zhang X, Chan AW. Developmental Whole Brain White Matter Alterations in Transgenic Huntington's Disease Monkey. Sci Rep. 2017;7:379. PMID: 28336929; PMCID: PMC5428287.

Dharmadhikari S, Galt JR, Nye JA. Hallway Conversations in Physics (What Is the Typical Effective Dose From a Routine Eye-to-Thigh PET/CT Examination Assuming an Injected 18F-FDG Dose of 370 MBq?). AJR Am J Roentgenol. 2017 Mar;208(3):W129-W130. PMID: 28095018.

Perez Diaz M, Andersen ML, Rice KC, Howell LL. Effects of a Serotonin 2C Agonist and a 2A Antagonist on Actigraphy-Based Sleep Parameters Disrupted by Methamphetamine Self-Administration in Rhesus Monkeys. Neuropsychopharmacology 2017;42(7):1531-1538. PMID: 27986974; PMCID: PMC5436115.

Raper J, Morrison RD, Daniels JS, Howell L, Bachevalier J, Wichmann T, Galvan A. Metabolism and Distribution of Clozapine-N-oxide: Implications for Nonhuman Primate Chemogenetics. ACS Chem Neurosci. 2017. PMID: 28324647; PMCID: PMC5522181.

Lipowska, Malgorzata; Jarkas, Nashwa; Voll, Ronald J.; Nye, Jonathon A.; Klenc, Jeffrey; Goodman, Mark M.; Taylor, Andrew T. Re(CO)3([18F]FEDA), a novel 18F PET renal tracer: Radiosynthesis and preclinical evaluation. Nuclear Medicine and Biology, 2018, 58:42-50.


Adhikarla V, Zeng F, Votaw JR, Goodman MM, Nye JA. Compartmental modeling of [(11)C]MENET binding to the norepinephrine transporter in the healthy human brain. Nucl Med Biol. 2016;43(5):318-23. PMID: 27150035; PMCID: PMC4860207.

Berro LF, Andersen ML, Tufik S, Howell LL. Actigraphy-based sleep parameters during the reinstatement of methamphetamine self-administration in rhesus monkeys. Exp Clin Psychopharmacol. 2016;24(2):142-6. PMID: 26882419. PMCID: PMC4795967.

Gopinath K, Maltbie E, Urushino N, Kempf D, Howell L. Ketamine-induced changes in connectivity of functional brain networks in awake female nonhuman primates: a translational functional imaging model. Psychopharmacology (Berl). 2016 Oct; 233(21-22): 3673-3684. PMID: 27530989.

Maltbie E, Gopinath K, Urushino N, Kempf D, Howell L. Ketamine-induced brain activation in awake female nonhuman primates: a translational functional imaging model. Psychopharmacology (Berl). 2016;233(6):961-72. PMID: 26660447. PMCID: PMC4761287.

Pippin AB, Mohd Arshad ZH, Voll RJ, Nye JA, Ghassabian S, Williams CM, Mancini A, Liotta DC, Smith MT, Goodman MM. In Vitro Metabolic Stability and in Vivo Biodistribution of 3-Methyl-4-furoxancarbaldehyde Using PET Imaging in Rats. ACS Med Chem Lett. 2016;7(6):563-7. eCollection 2016 PMID: 27326327; PMCID: PMC4904252.

Gopinath K, Maltbie E, Urushino N, Kempf D, Howell L. Ketamine-induced changes in connectivity of functional brain networks in awake female nonhuman primates: a translational functional imaging model. Psychopharmacology (Berl). 2016;233(21-22):3673-84. doi: 10.1007/s00213-016-4401-z. PMID: 27530989.

Meng Y, Hu X, Bachevalier J, Zhang X. Decreased functional connectivity in dorsolateral prefrontal cortical networks in adult macaques with neonatal hippocampal lesions: Relations to visual working memory deficits. Neurobiol Learn Mem. 2016;134 Pt A:31-37. PMID: 27063864; PMCID: 6329462.

Zhang X, Li CX. Arterial spin labeling perfusion magnetic resonance imaging of non-human primates. Quant Imaging Med Surg. 2016 Oct;6(5):573-581. PMID: 27942478; PMCID: PMC5130565.


Chan AW, Jiang J, Chen Y, Li C, Prucha MS, Hu Y, Chi T, Moran S, Rahim T, Li S, Li X, Zola SM, Testa CM, Mao H, Villalba R, Smith Y, Zhang X, Bachevalier J. Progressive cognitive deficit, motor impairment and striatal pathology in a transgenic Huntington disease monkey model from infancy to adulthood. PLoS One. 2015;10(5):e0122335. PMID: 25966278; PMCID: PMC4428630.

Dehkharghani S, Mao H, Howell L, Zhang X, Pate KS, Magrath PR, Tong F, Wei L, Qiu D, Fleischer C, Oshinski JN. Proton resonance frequency chemical shift thermometry: experimental design and validation toward high-resolutionnoninvasive temperature monitoring and in vivo experience in a nonhuman primate model of acute ischemic stroke. AJNR Am J Neuroradiol. 2015;36(6):1128-35. PMID: 25655874. PMCID: PMC4894329.

Li CX, Herndon JG, Novembre FJ, Zhang X. A longitudinal magnetization transfer imaging evaluation of brain injury in a macaque model of neuroAIDS. AIDS Res Hum Retroviruses. 2015;31(3):335-41. PMID: 25376011; PMCID: PMC4347891.

Meng Y, Zhang X. Transcallosal connectivity changes from infancy to late adulthood: an ex vivo diffusion spectrum imaging study of macaque brains. Brain Connect. 2015;5(3):147-55. PMID: 25389564; PMCID: PMC4394181.

Murnane KS, Gopinath KS, Maltbie E, Daunais JB, Telesford QK, Howell LL. Functional connectivity in frontal-striatal brain networks and cocaine self-administration in female rhesus monkeys. Psychopharmacology (Berl). 2015;232(4):745-54. PMID: 25138647; PMCID: 4310796.

Howell LL, Cunningham KA. Serotonin 5-HT2 receptor interactions with dopamine function: implications for therapeutics in cocaine use disorder. Pharmacol Rev.2015;67(1):176-97. PMID: 25505168. PMCID: PMC4279075.

Stehouwer JS, Birnbaum MS, Voll RJ, Owens MJ, Plott SJ, Bourke CH, Wassef MA, Kilts CD, Goodman MM. Synthesis, F-18 radiolabeling, and microPET evaluation of 3-(2,4-dichlorophenyl)-N-alkyl-N-fluoroalkyl-2,5-dimethylpyrazolo[1,5-a]pyrimidin -7-amines as ligands of the corticotropin-releasing factor type-1 (CRF1) receptor. Bioorg Med Chem. 2015;23(15):4286-302. PMID: 26145817; PMCID: PMC4516694.

Stehouwer JS, Bourke CH, Owens MJ, Voll RJ, Kilts CD, Goodman MM. Synthesis, binding affinity, radiolabeling, and microPET evaluation of 4-(2-substituted-4-substituted)-8-(dialkylamino)-6-methyl-1-substituted-3,4-dihyd ropyrido[2,3-b]pyrazin-2(1H)-ones as ligands for brain corticotropin-releasing factor type-1 (CRF1) receptors. Bioorg Med Chem Lett. 2015;25(22):5111-4. PMID: 26456805; PMCID: PMC4628894.

Tong, F., Zhang, X., Kempf, D., Yepes, M. Stroud, F. Zola, S. and Howell, L. A new model of middle cerebral artery occlusion in nonhuman primates using an endovascular trapping technique, AJNR Am J Neuroradiol. 2015, 36(12):2354-9. PMID:26381560. PMCID: PMC4681620.

Young MB, Andero R, Ressler KJ, Howell LL. 3,4-Methylenedioxymethamphetamine facilitates fear
extinction learning. Transl Psychiatry. 2015;5: e634. PMID: 26371762. PMCID: PMC5068803.

Zhang X, Tong F, Li CX, Yan Y, Kempf D, Nair G, Wang S, Muly EC, Zola S, Howell L. Temporal evolution of ischemic lesions in nonhuman primates: a diffusion and perfusion MRI study. PLoS One. 2015 Feb 6;10(2):e0117290. eCollection 2015. Erratum in: PLoS One. 2015;10(3):e0123613. PMID: 25659092; PMCID: PMC4319749.

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